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Title: Influence of heat shock protein 90 inhibitors and HGF-C-MET axis inhibitors on rhabdomyosarcoma cells biology

Abstract:

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma and accounts on c.a. 5% of all malignant tumors of childhood and adolescence. Newly diagnosed patients, without metastasis, have good prognosis, while patients with metastasis, have poor outcome (the overall survival rate - c.a. 20%). The goal of this dissertation was to evaluate utility of given strategies in treatment of RMS: usage of heat shock protein 90 inhibitors - geldanamycin and its analogues, targeting the multiple cancer-causing pathways and usage of siRNA inhibiting MET receptor, known to be responsible for cancer invasion and metastasis. We found that geldanamycin causes apoptosis and cell cycle arrest, which result in RMS cells growth inhibition. Geldanamycin reduces MET-dependant invasiveness and homing into bone marrow. We observed higher sensitivity of embryonal subtype in comparison with alveolar RMS subtype to heat shock protein 90 inhibitors. We showed that MET receptor blockage results in decrease of RMS invasiveness and primary tumor growth inhibition, due to proliferation restriction, differentiation and angiogenesis reduction. It seems that the strategies described above could be of a value when considering potential, new therapeutic approaches in RMS therapy.

Level of degree:

2 - studia doktoranckie

Degree discipline:

onkologia

Degree grantor:

Wydział Lekarski

Promoter:

Marcin Majka

Date issued:

2007

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:991

Call number:

ZB-107468

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Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

Object collections:

Last modified:

Jun 25, 2019

In our library since:

Nov 21, 2012

Number of object content hits:

10

Number of object content views in PDF format

9

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/991

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ZB-107468 Jun 25, 2019
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