Object

Title: The physicochemical analysis of propolis and the possibility of its standardization

Abstract:

The subject of this analysis is ethanolic extracts of propolis from the area of Poland which have been analyzed to establish their chemical composition and identify biological active compounds. As a result of the analysis chemical compounds such as caffeic acid, ferulic acid, p-coumaric acid, pinocembrin, pinobanksine acetate, galangin, chrysin, phenylethyl caffeate and 1,1–dimethylallyl caffeate were identified and determined. Samples were examined to appreciate their antibacterial activity in relation to Staphylococcus aureus and antifungal activity in relation to Candida albicans. For the purpose of studying antioxidant activity the CUPRAC method was used. Results were performed in relation to trolox. The samples showed high antioxidant activity and results ranged from 49,5 mmol/g to 78,0 mmol/g. Concentration of each compound was compared with antibacterial, antifungal and antioxidant activity. For assessment the indirect analysis of standards and their model mixtures as well as the statistic methods were applied. In search of active compounds a choice of propolis tinctures were fractioned using column chromatography. The fractions were analyzed by HPLC, GC-MS and their antimicrobial activity was evaluated. In the evaluation of products assigned for therapy, except for the determination of active compounds, the examination of their purity was taken into consideration so that the contents of cupric, zinc, iron, cadmium and lead’s ions was determined.

Level of degree:

2 - studia doktoranckie

Degree discipline:

chemia ; farmacja

Degree grantor:

Wydział Farmacji

Promoter:

Jan Krzek

Date issued:

2007

Format:

text/html

Identifier:

oai:dl.cm-uj.krakow.pl:960

Call number:

ZB-106518

ControlNumberVIRTUA:

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Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

Object collections:

Last modified:

Jun 25, 2019

In our library since:

Nov 21, 2012

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All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/960

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ZB-106518 Jun 25, 2019
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