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Michałowska-Kaczmarczyk, Anna
2007
Praca doktorska
It is assumed that small number of tissue-specific progenitor cells circulate in peripheral blood and the intensified mobilization of the cells from tissue niches, mainly from bone marrow, occurs during acute myocardial infarction. An increase in the number of circulating CD34+, CD117+, c-met+ and CXCR4+ cells in peripheral blood during early period of acute myocardial infarction has been indicated from results of the tests. Simultaneously, a growth in expression of mRNA for cardiac, muscular and endothelial markers among circulating mononuclear cells has been observed. Intensified mobilization of hematopoetic progenitors has been stated in clonogenic in vitro tests. The results of the tests confirmed the hypothesis assuming that the stress involved with myocardial infarction mobilizes tissue-derived stem cells–from tissue niches to peripheral blood. Mobilization of the cells is accompanied by some changes in cytokine concentration in peripheral blood (an increase in VEGF, IL-6, G-CSF and HGF, and a decrease in serum level of SDF-1). The results obtained in the dissertation suggest not only the possibility of circulation of heterogenic population of stem cells in blood but also confirmed the mobilization induced by organ damage in the course of myocardial infarction.
Kraków
2 - studia doktoranckie
choroby układu krążenia ; fizjologia ; transplantologia
Wydział Lekarski
Ratajczak, Mariusz
oai:dl.cm-uj.krakow.pl:950
ZB-106436
pol
tylko w bibliotece
Feb 4, 2023
Nov 21, 2012
13
0
http://dl.cm-uj.krakow.pl:8080/publication/950
RDF
OAI-PMH
Borówka, Magdalena
Rzepecka-Woźniak, Ewa
Grzymała-Lubańska, Joanna
Mołek-Dziadosz, Patrycja
Wojdyła, Roman
Stępień, Konrad
Musiał-Wysocka, Aleksandra
Citation style: chicago-author-date iso690-author-date chicago-author-date
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