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Title: Circulation of early hematopoetic, muscle, cardiac, and endothelial tissue-commited stem cell during myocardial infarction

Abstract:

It is assumed that small number of tissue-specific progenitor cells circulate in peripheral blood and the intensified mobilization of the cells from tissue niches, mainly from bone marrow, occurs during acute myocardial infarction. An increase in the number of circulating CD34+, CD117+, c-met+ and CXCR4+ cells in peripheral blood during early period of acute myocardial infarction has been indicated from results of the tests. Simultaneously, a growth in expression of mRNA for cardiac, muscular and endothelial markers among circulating mononuclear cells has been observed. Intensified mobilization of hematopoetic progenitors has been stated in clonogenic in vitro tests. The results of the tests confirmed the hypothesis assuming that the stress involved with myocardial infarction mobilizes tissue-derived stem cells–from tissue niches to peripheral blood. Mobilization of the cells is accompanied by some changes in cytokine concentration in peripheral blood (an increase in VEGF, IL-6, G-CSF and HGF, and a decrease in serum level of SDF-1). The results obtained in the dissertation suggest not only the possibility of circulation of heterogenic population of stem cells in blood but also confirmed the mobilization induced by organ damage in the course of myocardial infarction.

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia ; fizjologia ; transplantologia

Degree grantor:

Wydział Lekarski

Promoter:

Mariusz Z. Ratajczak

Date issued:

2007

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:950

Call number:

ZB-106436

ControlNumberVIRTUA:

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Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

Object collections:

Last modified:

Feb 12, 2020

In our library since:

Nov 21, 2012

Number of object content hits:

7

Number of object content views in PDF format

6

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/950

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Edition name Date
ZB-106436 Feb 12, 2020

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