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Title: Selected parameters of the peripheral blood monocytes fenotype in the group of patients with risk factors of atherosclerosis

Abstract:

Atherosclerosis is a chronic inflammatory process with the dominant role of peripheral blood monocytes. The object of the study was the analysis of the relationship between conventional risk factors of atherosclerosis, such as hypercholesterolaemia, diabetes mellitus, arterial hypertension, overweight or smoking, and individual monocyte subpopulations, selected on the basis of the presence or absence of CD14 and CD16 antigens, as well as the determination of the connection between vascular endothelium function and the differential monocyte count in the group of patients with risk factors. All selected monocyte subpopulations showed statistically significant dependencies, between the number of risk factors and individual monocyte subpopulations, especially in case of so-called “proinflammatory” monocytes with concurrent expression of CD16 and CD14 antigens. The most evident relationship occurs between the differential monocyte count and arterial hypertension, especially in case of CD16+CD14+ and CD16+CD14+ high monocytes. In patients with arterial hypertension, those monocytes show especially proinflammatory character, connected with the overproduction of TNFα. There is an association between the hypertension control and differential count of proinflammatory monocytes subpopulations. The association between the endothelial function (measured as FMD) and differential monocyte count has not been proved. Conclusions: Monocytes CD16+CD14+high and CD16+CD14+dim can be treated as a marker of the inflammation in the group of patient with hypertension.

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Tomasz Guzik

Date issued:

2009

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:929

Call number:

ZB-110914

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Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

Object collections:

Last modified:

Sep 12, 2019

In our library since:

Nov 21, 2012

Number of object content hits:

6

Number of object content views in PDF format

6

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/929

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ZB-110914 Sep 12, 2019
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