Object

This publication is protected and available only for logged users.
This publication is protected and available only for logged users.

Title: Analytical assessment of azole antifungal drugs

Abstract:

The subject of this dissertation is analytical assessment of selected azole antifungal substances; bifonazole, econazole, fluconazole, itraconazole, ketoconazole, clotrimazole and miconazole. Elaboration of new methods of qualitative identification, quantitative determination, separation and also elements of purity assessment was done. For above mentioned purposes three analytical techniques were used; UV-Vis spectrophotometry including derivative spectrophotometry, thin-layer chromatography (TLC) with densitometric detection and capillary gas chromatography with flame-ionisation detection (CGC-FID). Methods presented in this thesis were validated and their usefulness in routine pharmaceutical analysis is proven. Many innovative procedures were described. Spectrophotometric procedure for itraconazole is prepared for the first time. Bifonazole, econazole, ketoconazole, clotrimazole and miconazole were not determined by using CGC-FID till now. Researches with itraconazole on gas chromatography, presented in this dissertation, could be useful in additional qualitative analysis. Separation of all investigated azoles done using GC and separation for 4 azoles (bifonazole, fluconazole, itraconazole and ketoconazole) by TLC is also innovate. Elaborated methods are valuable alternative and supplementation of investigational possibilities in the group of azole antifungal drugs for the routine pharmaceutical analysis purposes. They are important for quality assurance of substances under consideration.

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmacja ; chemia

Degree grantor:

Wydział Farmacji

Promoter:

Jan Krzek

Date issued:

2009

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:917

Call number:

ZB-110276

ControlNumberVIRTUA:

click here to follow the link

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

Object collections:

Last modified:

Nov 19, 2019

In our library since:

Nov 21, 2012

Number of object content hits:

13

Number of object content views in PDF format

13

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/917

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-110276 Nov 19, 2019

Objects

Similar
×

Citation

Citation style:

This page uses 'cookies'. More information