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Title: Adenomatous colon polyps dysplasia and microsatellite instability

Author:

Matłok, Maciej

Date:

2009

Type:

Praca doktorska

Abstract:

Our aim is to analyze microsatellite instability (MSI) in polyps of the large intestine removed during endoscopic polypectomy. A total 97 patients (30 female and 67 male) were included into the study group. In those patients we performed polypectomy between 2004 and 2007 in the 2nd Department of Surgery, Jagiellonian University, Krakow. Thus allowed us to gather DNA from the polyp specimen and amplify it with polymerase chain reaction (PCR) with 5 primers for APC, p-53, BAX, BATR II and BAT-26 genes.In case of microsatellite instability in at least one of these 5 loci, another PCR products were tested using ABI PRISM 310 Genetic Analyser. In 97 patients we removed altogether 130 adenomatous polyps. The most frequent location for them was the sigmoid colon. Microsatellite instability was detected in 21 polyps (16,6%), loss of heterozygosity in 25 polyps (19%). In control colonoscopy performed 1 year later recurrence of polyps was detected in 15% patients (7% female, 15% male). Microsatellite instability in p53, DCC were the most frequent mutation loci. It is also characteristic that recurrence of polyps appears more often in patients with MSI.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu trawiennego

Degree grantor:

Uniwersytet Jagielloński – Collegium Medicum

Promoter:

Karcz, Danuta

Date issued:

2009

Identifier:

oai:dl.cm-uj.krakow.pl:910

Call number:

ZB-110242

Language:

pol

Access rights:

nieograniczony

Subject and keywords:

microsatellite instability microsatellite DNA colon polyp colon cancer

Object collections:

Last modified:

Jun 26, 2023

In our library since:

Nov 21, 2012

Number of object content hits:

4 752

Number of object content views in PDF format

400

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/910

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Edition name Date
ZB-110242 Jun 26, 2023

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