Object

Title: Evaluation of the influence of Id2 protein on prognosis in children with neuroblastoma

Abstract:

The aim of this study was evaluation of the Id2 protein expression in neuroblastoma (NBL), including its influence on overall survival (OS) and disease free survival (DFS) as well as its correlation with known prognostic factors. The analysis of selected prognostic factors and their influence on OS and DFS was performed. In the years 1991-2005, among 100 patients treated for NBL 60 were evaluated. Id2 protein expression was examined by immunohistochemistry on paraffin embedded tumor tissue. All 60 analyzed tumors showed presence of Id2 protein expression. The evaluated tumors differed in the intensity of expression and the percentage of Id2 positive cells. The intensity of expression and percentage of cells had no influence on OS and DFS. There was no correlation with presence of other risk factors. In the whole group and in patients without MYCN amplification it can be supposed that there is a tendency to lower OS in patients with strong Id2 expression in NBL cells (p=0,07 and p=0,08, respectively). In the group without MYCN amplification there was a tendency to higher risk of disease relapse or progression in patients with stronger intensity of Id2 expression (p=0,05). The most important prognostic factors remained MYCN amplification and stage of disease. Although Id2 is not a prognostic factor in NBL, due to its abundant presence in NBL cells may be a potential therapeutic target.

Level of degree:

2 - studia doktoranckie

Degree discipline:

onkologia ; pediatria

Degree grantor:

Wydział Lekarski

Promoter:

Walentyna Balwierz

Date issued:

2008

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:870

Call number:

ZB-109594

ControlNumberVIRTUA:

click here to follow the link

Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

Object collections:

Last modified:

Sep 3, 2019

In our library since:

Nov 21, 2012

Number of object content hits:

1 076

Number of object content views in PDF format

1073

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/870

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-109594 Sep 3, 2019
×

Citation

Citation style:

This page uses 'cookies'. More information