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Title: Measurement of bronchoconstrictive eicosanoides in chronic obstructive pulmonary disease

Abstract:

Objective: In the thesis presented the evaluation of systemic production of PGD2 and leukoriene E4 (LTE4) was undertaken in stable and exacerbated COPD patients. Methods: 29 COPD patients aged 73 ± 8,34, mean FEV1= 48,64 ± 15,75% of predictive value and 29 healthy controls aged 57,48 ± 10,86, mean FEV1= 97,17 ± 13,81% of predictive value participated in this study. Samples of urine and blood were taken from COPD patients during exacerbation and in stable state of the disease. LTE4 was determined in urine using commercial enzyme immunoassay (EIA) and 9ɑ11βPGF2 – stable metabolite of PGD2 was evaluated in blood and urine using gas chromatography/mass spectrometry. The concentration of tryptase and C- reactive protein were determined in blood at the same time. Results: LTE4 concentration in urine and 9ɑ11βPGF2 in blood were significantly higher in exacerbated COPD patients than in healthy controls. There was no difference in LTE4 level in urine and 9ɑ11βPGF2 in blood between exacerbated and stable COPD. The urinary 9ɑ11βPGF2 concentration did not differ between all studied groups. In contrary, the CRP concentration was significantly higher in exacerbation of COPD compared to the stable state of the disease and control group. The tryptase level was lower during COPD exacerbation than in the control group and in stable patients. We found a positive correlation between smoking history and urine LTE4 as well as blood 9ɑ11βPGF2 concentrations in COPD patients. No correlation was observed between systemic eicosanoides production and severity of the disease as well as severity of exacerbation.

Level of degree:

2 - studia doktoranckie

Degree discipline:

pulmonologia

Degree grantor:

Wydział Lekarski

Promoter:

Krzysztof Sładek

Date issued:

2008

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:861

Call number:

ZB-109401

ControlNumberVIRTUA:

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Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

Object collections:

Last modified:

Feb 13, 2020

In our library since:

Nov 21, 2012

Number of object content hits:

12

Number of object content views in PDF format

11

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/861

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ZB-109401 Feb 13, 2020
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