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Title: Adaptive changes after repeated treatment with antagonists of group I metabotropic glutamate receptors

Abstract:

The aim of this study was to investigate several adaptive changes after repeated treatment with antagonists of group I metabotropic glutamate receptors: MPEP and MTEP and to compare these changes with effects induced by conventional antidepressants. Receptor adaptive changes, after chronic administration of MTEP, were determined in rats brain. The results of our studies showed significant α1-up-regulation and no influence on β- and α2-adrenergic receptor. In glutamatergic system, chronic MTEP administration, produced a significant increase of mGluR5 receptor density in hippocampus and cortex. We also observed reduction of glycine affinity to glycine site of the NMDA receptor complex. Multiple MTEP administration, has no effect on 5-HT1A and 5- HT2A serotonergic receptors. Changes in NMDA, α1 and mGluR5 receptors are similar to these induced by antidepressant drugs. Chronic treatment with MPEP, but not MTEP, produced a significant increace BDNF expression in the rat hippocampus. Antidepressant-like activity of MTEP, in Porsolt test is dependent on 5-HT2A and NMDA receptors activity. Involvement of 5-HT1A and AMPA receptors was no observed. The results indicate that interaction between mGluR I and NMDA receptors, as well as between mGluR I and 5-HT-receptors play a role in antidepressant mechanism. In conclusion, these data show some similarities in mechanism of action between group I mGluR antagonists (MTEP) and conventional antidepressants and suggest their potent activity in clinical depression.

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmakologia

Degree grantor:

Wydział Lekarski

Promoter:

Gabriel Nowak

Date issued:

2008

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:860

Call number:

ZB-109400

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Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

Object collections:

Last modified:

Feb 10, 2020

In our library since:

Nov 21, 2012

Number of object content hits:

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Number of object content views in PDF format

8

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/860

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ZB-109400 Feb 10, 2020
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