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Title: Obstructive form of hypertrophic cardiomyopathy is associated with enhanced thrombin generation, inflammatory response and platelet activation

Abstract:

The purpose of this study was to exam the association of left ventricular outflow tract (LVOT) obstruction with blood coagulation, platelet activity and inflammatory response in patients with hypertrophic cardiomyopathy (HCM) and sinus rhythm. Additionally it was found the correlation between the level of markers (particulary cytokines), and increased arrhythmogenic activity. 42 patients with HCM and sinus rhythm were included to the study. 16 patients with resting LVOT obstruction (gradient > or = 30 mm Hg). The control group consisted of 42 volunteers without essential disorders, matched according to sex and age, body mass index, occurring lipid disorders, cigarettes smoking and diabetes. In the study markers of thrombin generation (TAT, F1+2); platelet activation (sCD40L, β-TG, P-selectin); inflammation (hsCRP, IL-6, TNFα) were determined. Thrombin, platelet and inflammatory markers were higher in the entire HCM group than in controls (p<0.005 for all compared parameters). For this process LVOT with following subvalvue gradient is responsible. Left ventricular outflow tract obstruction was independent predicor for TAT (R2= 0,61; p=0,0003), for sCD40L (R2=0,59; p=0,0008), for F1+2 (R2=0,55; p=0,002), for P- selectin (R2=0,49; p=0,004),for β-TG (R2=0,38; p=0,005). This study showed that LVOT obstruction was associated with increased thrombin formation, platelet activation and both hs-CRP and IL-6 levels. Only the level of TNF-α was similar in both forms of HCM. Increased of thrombin activity was correlated with increased platelet activity and inflammatory markers in patients with HCM and in control group. Non sustained ventricular tachycardia in patients with HCM, confirmed during Holter EKG monitoring was correlated with increase level of TNF-α.

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Paweł Petkow-Dimitrow

Date issued:

2008

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:858

Call number:

ZB-109398

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Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

Object collections:

Last modified:

Nov 18, 2019

In our library since:

Nov 21, 2012

Number of object content hits:

4

Number of object content views in PDF format

4

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/858

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ZB-109398 Nov 18, 2019
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