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Title: Contrast-induced nephropathy in patients undergoing angiography and angioplasty procedures

Abstract:

Contrast-induced nephropathy (CIN) is a serious complication after exposure to iodinated contrast media. Recent studies show that N-acetylcysteine may play a significant role in prevention of CIN. The aim of his study was to evaluate the incidence of contrast-induced nephropathy in patients undergoing angiography and/or angioplasty procedures, to asses the efficacy of intravenous N-acetylcysteine in prevention of this complication and to asses the long term adverse effects of contrast-induced nephropathy. Results: Contrast-induced nephropathy was observed in 18,4% patients undergoing angiography and/or angioplasty procedures. The incidence of CIN was significantly reduced in patients receiving intravenous N-acetylcysteine as compared to patients receiving hydration with normal saline alone. The search for independent risk factors of contrast-induced nephropathy was performed. This revealed the following predictors: diabetes mellitus and impaired renal function (with eGFR < 60 ml/min/1,72m²), heart failure and volume of contrast medium administered. The risk of CIN was reduced in patients administered isoosmolal contrast medium. Probability of survival free of the following adverse events : cardiovascular death, heart infarct, dialysis, rehospitalization due to cardiac or renal causes was reduced in patients with contrast-induced nephropathy. Conclusions: The rate of long-term adverse events was higher in patients with contrast-induced nephropathy. Administration of intravenous N-acetylcysteine reduces the risk of CIN.

Level of degree:

2 - studia doktoranckie

Degree discipline:

nefrologia

Degree grantor:

Wydział Lekarski

Promoter:

Piotr Odrowąż-Pieniążek

Date issued:

2010

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:826

Call number:

ZB-113634

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Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

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Last modified:

Oct 14, 2019

In our library since:

Nov 21, 2012

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Number of object content views in PDF format

5

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/826

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ZB-113634 Oct 14, 2019
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