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Title: Genetic risk factors for development of bronchopulmonary dysplasia in preterm infants

Author:

Janeczko, Magdalena

Date:

2010

Type:

Praca doktorska

Abstract:

Improved survival of extremely preterm infants has been associated with increased incidence of bronchopulmonary dysplasia (BPD). The candidate genes for BPD development in the present study were chosen because of their potential involvement in free radical eliminations and inflammation. The analysis of the association of different polymorphisms of the following genes: GSTP1, GSTM1, GSTT1, EPHX1 and TNF- with the risk of BPD development was performed. The study group included 98 preterm infants with BPD. 294 babies served as a control group (preterm infants with no BPD and the full-term healthy neonates). TNF--308 genetic polymorphism, GSTM1*0/*0, GSTT1*0/*0 and GSTT1*0/*0/GSTM1*0/*0 genotype show lack of significant association with increased risk of BPD. Our results have not revealed that the presence of GSTP1*B genetic polymorphism, TNF--238 genetic polymorphism or 415A>G genetic polymorphism of EPHX1 gene is connected with decreased risk of BPD. Observed frequency of 337C allele as well as 337CC genotype has been higher in the cases corresponding to the controls. These results suggest that 337CC genotype may be associated with BPD. Nevertheless, further studies are needed to investigate the role of polymorphic variants as possible risk factors for BPD development. This might provide the means for better BPD prevention and could help in the development of new treatments.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

pulmonologia ; pediatria

Degree grantor:

Wydział Lekarski

Promoter:

Pietrzyk, Jacek J.

Date issued:

2010

Identifier:

oai:dl.cm-uj.krakow.pl:824

Call number:

ZB-113632

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

gene polymorphisms inflammation bronchopulmonary dysplasia prematurity oxidative stress

Object collections:

Last modified:

Mar 15, 2023

In our library since:

Nov 21, 2012

Number of object content hits:

19

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/824

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Edition name Date
ZB-113632 Mar 15, 2023

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