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Title: The effect of statin on biochemical calcification markers of aortic stenosis – estimation in correlation to different degree of stenosis

Author:

Jawień, Marek

Date:

2010

Type:

Praca doktorska

Abstract:

Nowadays, aortic stenosis is the most frequent valvular failure in Europe and in the United States. The aim of the research was to estimate plasma level of osteoprotegerin, osteopontin as well as soluble ligand of receptor activator of nuclear factor kB – sRANKL in patients with small degenerative changes of aortic valve – aortic sclerosis or aortic stenosis of a low degree. Moreover, the level of inflammatory markers: C-reactive protein (CRP), interleukin 6 (IL-6) and monocyte chemotactic protein – 1 (MCP-1) were measured. Finally, 33 patients were included to the experiment (18 men and 15 women, mean age: 70±8). Plasma levels of OPG, OPN and sRANKL were measured. Inflammatory markers: hsCRP, IL-6 and MCP-1. After blood taking, echocardiography was performed in all examined patients. Atorvastatin in a dose of 20 mg were given to patients for 4 weeks. After 4 weeks of therapy, blood samples were taken once again from the patients and the same markers were measured. The plasma level of 3 calcification markers (OPG, sRANKL, OPN) were decreased after atorvastatin, however, OPN reduction did not reach statistical significance. The estimation of inflammatory markers revealed that all three (CRP, IL-6 and MCP-1) were significantly decreased after therapy. From the above results, the following conclusions were given: In patients with aortic sclerosis or small aortic stenosis 20 mg of atorvastatin: 1. reduces levels of calcification and inflammation biomarkers 2. this reduction is comparable between patients with and without hypercholesterolemia 3. the presence of atherosclerotic plaque/plaques in carotid artery does not influence assessed biomarkers.

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Paweł Petkow-Dimitrow

Date issued:

2010

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:808

Call number:

ZB-113476

ControlNumberVIRTUA:

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Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

Subject and keywords:

aortic stenosis atorvastatin osteoprotegerin

Object collections:

Last modified:

Oct 8, 2019

In our library since:

Nov 21, 2012

Number of object content hits:

502

Number of object content views in PDF format

512

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/808

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OAI-PMH

Edition name Date
ZB-113476 Oct 8, 2019

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