Object

Title: Imaging of unspecific inflammation within carotid artery wall in scintigraphy with the use of radiolabeled interleukin – 2 in ESRD patients at high cardiovascular risk

Abstract:

Introduction: The histological studies of the atherosclerotic plaque (AP) have revealed that at least 20% of inflammatory cells within unstable plaque contain receptors for interleukin 2 (IL-2); these receptors can be identified with scintigraphy with radiolabeled IL-2. Material and methods: 38 ESRD patients were included to the study. All of them underwent scintigraphy with the use of IL-2 labeled iodine-123 (10 patients with the highest cardiovascular risk (aged 62,4 ± 10,4)) or technetium-99m (28 patients, aged 55,2 +/- 9,6). Additionally CCA-IMT and concentrations of some biochemical factors were measured. Target/non-target ratio of IL-2 uptake with CCA-IMT and concentration of measured agents were compared. Results: Increased 123I-IL-2 uptake in 16/16 (100%) carotid AP previously revealed by ultrasounds were detected. Mean target/non-target ratio (T/nT) was 3,15 ± 0,54 (range 2,0 – 3,6). Difference between T/nT ratio in the group of patients with and without cardiovascular event during 36 months observation period was observed (3,45 +/- 0,22 vs 2,91 +/- 0,54, p = 0,046). Mean T/nT ratio of 99mTcIL-2 uptake in AP was 2,34 ± 0,70 (range 1,23– 3,63). Significant dependence between scintigraphy results and hemoglobin (R = - 0,21, p = 0,02), homocysteine (R = 0,22, p = 0,037), apo B (R = 31, p = 0,008), apoB/apoA-I ratio (R= 0,29, p= 0,012) and triglycerides concentration (R = 0,26, p = 0,021) were detected. Conclusions: Scintigraphy with the use of labeled IL-2 enables visualization of inflamed atherosclerotic (vulnerable) plaque within common carotid arteries in ESRD patients and may be a tool for short-term evaluation of cardiovascular risk.

Level of degree:

2 - studia doktoranckie

Degree discipline:

urologia ; choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Alicja Hubalewska-Dydejczyk

Date issued:

2009

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:769

Call number:

ZB-111778

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Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

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Last modified:

Oct 2, 2019

In our library since:

Nov 21, 2012

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743

Number of object content views in PDF format

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All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/769

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ZB-111778 Oct 2, 2019
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