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Title: Antinociceptive action of locally administrated tricyclic antidepressants after sciatic nerve ligation - the rat model of neuropathic pain

Abstract:

In our investigations, the topical use of antidepressants (amitriptyline, doxepine, venlafaxine) on neuropathic pain development was examined. Neuropathic pain, the result of neuropathy, was evoked by constriction chronic injury of the sciatic nerve in rats. The results of locally administered antidepressants on pain behavior were assessed. Antidepressants used in the study were administered into the ventral part of paw affected with neuropathy. For the study of pain behavior we used von Frey’s test for allodynia and paw withdrawal test for hyperalgesia. Analysis of interactions between topically administered antidepressants and morphine and influence of serotoninergic, adrenergic and opioid systems on effects of antidepressants were examined. All three studied drugs reduce development of allodynia, but only tricyclic antidepressants reduce hyperalgesia. We found that inactivation of opioid, adrenergic and serotoninergic systems abolishes the inhibitory actions of the studied drugs on development of allodynia or hyperalgesia. The analgesic effects of morphine were potentiated by concomitant administration of amitryptyline and attenuated by coadministration of doxepine or venlafaxine.

Level of degree:

2 - studia doktoranckie

Degree discipline:

anestezjologia

Degree grantor:

Wydział Lekarski

Promoter:

Jerzy Wordliczek

Date issued:

2009

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:756

Call number:

ZB-111535

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Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

Object collections:

Last modified:

Oct 2, 2019

In our library since:

Nov 21, 2012

Number of object content hits:

3

Number of object content views in PDF format

3

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/756

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ZB-111535 Oct 2, 2019
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