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Title: Bioethical challenges of gene therapy and regenerative medicine
Abstract:
Gene therapy and regenerative medicine are biomedical technologies with promising therapeutic value. Significant research efforts are being made to advance the field of gene therapy, with a focus on developing regenerative medicine technologies. One of this research effort was funded by European Commission in 2020, a project called "Cartilaginous tissue regeneration by gene therapy; taking the hurdles towards efficient delivery" (acronym: CARTHAGO). The applicability of these potential therapies requires anticipating possible bioethical issues. The aim of the thesis is: i) to evaluate the bioethical challenges of somatic gene therapy and regenerative strategies for disc and joint pathology in the preclinical, laboratory phase; and ii) to promote and evaluate the integration of bioethics into preclinical research in CARTHAGO. Three studies were carried out to achieve the aims of the thesis. The first study contributed to the debate on the ethical and social dimensions of somatic gene therapy by providing a database of existing challenges and arguments. The second study helps to identify key ethical challenges. The third study provides a concrete strategy for embedding ethics and strengthening accountability in laboratory research. This thesis provides an assessment of the bioethical challenges associated with gene therapy and regenerative medicine for disc and joint pathology, a ; nd a proposal on how to integrate bioethics in preclinical biotechnology research in an international, multicenter and multidisciplinary consortium.
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Rada Dyscypliny Nauki o zdrowiu
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Last modified:
Mar 26, 2025
In our library since:
Mar 26, 2025
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http://dl.cm-uj.krakow.pl:8080/publication/5240
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| Edition name | Date |
|---|---|
| ZB-142297 | Mar 26, 2025 |
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