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Title: Biological disease-modifying anti-rheumatic drugs with a focus on rituximab in achieving remission and low disease activity in patients with rheumatoid arthritis and psoriatic arthritis

Author:

Łosińska, Katarzyna

Date:

2024

Type:

Praca doktorska

Abstract:

Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are the two most common chronic rheumatic diseases. Biological disease-modifying antirheumatic drugs (bDMARDs), both original and biosimilar, significantly increase the chances of achieving remission or low disease activity. However, the effects of therapy in everyday clinical practice differ from the results of clinical trials, which emphasizes the need to analyze real-world data. The aim of the study was to compare the efficacy of rituximab (RTX) and its biosimilar GP2013 in RA patients and to determine the relationship between the use of different bDMARDs and long-term changes in disease activity in PsA patients. Significant improvement in disease activity was shown in RA patients treated with RTX and stable efficacy of GP2013 comparable to the original drug. In PsA, an increase in the number of patients achieving remission was observed, which was associated with the introduction of new bDMARDs. Women with PsA achieved remission less often than men. The results varied significantly depending on the remission definition used, which indicates the need to revise the criteria for assessing both remission and low disease activity.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Korkosz, Mariusz ; Haugeberg, Glenn

Date issued:

2023

Identifier:

oai:dl.cm-uj.krakow.pl:5143

Call number:

ZB-141625

Language:

pol; eng

Access rights:

tylko w bibliotece

Subject and keywords:

Rheumatoid arthritis psoriatic arthritis rituximab GP2013 biosimilars

Object collections:

Last modified:

Jan 16, 2025

In our library since:

Jul 16, 2024

Number of object content hits:

6

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/5144

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Edition name Date
ZB-141625 Jan 16, 2025

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