This publication is unavailable to your account. If you have more privileged account please try to use it or contact with the institution connected to this digital library.
Woziwodzka, Karolina
2022
Praca doktorska
Renal impairment (RI) in multiple myeloma (MM) affects 50% patients, leads to increased morbidity. The aim of this study was to evaluate the utility of markers: IGFBP-7, TIMP-2, transgelin-2 and monomer NGAL in MM, the influence of neoplasm on their concentrations and interactions between them. The follow-up data included serum creatinine, eGFR, the date and cause of death. Elevated serum and urine levels of these biomarkers were observed. The urine concentration of monomer NGAL, IGFBP-7 and serum concentration of transgelin-2 correlated with the decrease of eGFR and higher disease stage. They may be considered predicative of future chronic kidney disease. Majority of tubular biomarkers correlate with one another; however transgelin-2 seems to be an independent marker. The early measurement of these biomarkers in MM patients allows to predict the development of chronic kidney injury. The idea of creation of biomarkers panels seems to be superior in future development of their use.
Kraków
2 - studia doktoranckie
hematologia ; nefrologia
Rada Dyscypliny Nauki medyczne
Krzanowska, Katarzyna
oai:dl.cm-uj.krakow.pl:4951
ZB-136329
pol; eng
tylko w bibliotece
Mar 25, 2024
Feb 28, 2023
5
0
http://dl.cm-uj.krakow.pl:8080/publication/4952
RDF
OAI-PMH
Banaszkiewicz, Małgorzata
Undas, Anetta
Jurczyszyn, Artur
Rakus, Anna
Walatek, Bogusław
Citation style: chicago-author-date iso690-author-date chicago-author-date
This page uses 'cookies'. More information I understand