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Title: The role of free circulating fetal nucleic acids in the etiopathogenesis of hypertension in pregnancy and pre-eclampsia and their diagnostic potential
Abstract:
Hypertension in pregnancy is considered to be a multifactorial disease, caused by a complex interaction between genetic, immunological and environmental factors, but there is no single hypothesis that would unequivocally explain the disease. Circulating free nucleic acids appear to be a valuable and promising marker of many diseases, including those of genetic origin. So far, no standardized quantification and reference values for free fetal DNA have been published for the population of patients with hypertension during pregnancy. In the study, blood tests were performed in two groups of pregnant patients - diagnosed with arterial hypertension in pregnancy and in the control group. The serum level of circulating free nucleic acids and DNAase activity in both groups were quantified. The differences in the level of cfDNA and the fetal fraction in the study and control groups were demonstrated, as well as a positive correlation with the occurrence of pregnancy complications. Higher cfDNA values were found in the group of patients with pre-eclampsia compared to the group of patients with isolated arterial hypertension, and significantly higher levels of cfDNA were found in the group of patients with early-onset pre-eclampsia. The presented study may help in the development of additional markers used in the diagnosis of hypertension in the course of pregnancy, and on the other ha ; nd, it potentially opens up new treatment options for this disease.
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Rada Dyscypliny Nauki medyczne
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Last modified:
Apr 8, 2024
In our library since:
Jan 23, 2023
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6
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0
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http://dl.cm-uj.krakow.pl:8080/publication/4919
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| Edition name | Date |
|---|---|
| ZB-136159 | Apr 8, 2024 |
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