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This publication is protected and can be accessed only from certain IPs.

Title: Assessment of the relationship between the gastrointestinal microbiota and the outcomes of bariatric surgery


The aim of the study was to compare the composition of the gastrointestinal microbiota of patients undergoing bariatric surgery who had favorable outcomes in terms of the excess weight loss with those who did not respond so positively to bariatric surgery. Patients underwent either sleeve gastrectomy or Roux-en-Y gastric bypass. The excess weight loss was assessed six months after surgery. Oral swabs and stool samples were collected from the patients before the surgery and during the follow-up visit, six months after the procedure. Based on the collected biological material, the composition of microbiota present in the oral cavity and large intestine was analyzed. Group 1 consisted of patients who achieved favorable outcomes - at least 50% excess weight loss. Group 2 comprised the remaining patients. Before the surgery, patients in group 1 had oral microbiota richer in Proteobacteria and Bacteroidetes, and intestinal microbiota more abundant in Proteobacteria. Patients in group 2 before the surgery had the oral microbiota richer in Actinobacteria and the large intestine microbiota more abundant in Bacteroidetes and Firmicutes. After six months, patients from group 1 had a greater number of Fusobacterium bacteria in their oral microbiota and more bacteria from phylum Firmicutes in their large intestine. Among patients from group 2, after six months, the oral microbiota was ; more abundant in bacteria of the phylum Actinobacteria, and the microbiota of the large intestine in bacteria of the phylum Bacteroidetes.

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2 - studia doktoranckie

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Wydział Lekarski


Major, Piotr

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pol; eng

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tylko w bibliotece

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Mar 6, 2024

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Apr 2, 2022

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Edition name Date
ZB-134475 Mar 6, 2024


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