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This publication is protected and can be accessed only from certain IPs.

Title: Selected elements of the pathogenesis of Clostridium difficile infection

Author:

Dróżdż, Mirosław

Date:

2021

Type:

Praca doktorska

Abstract:

The first study ("The presence of IL 8 +781 T/C polymorphism is associated with the parameters of severe Clostridium difficile infection") indicates that the presence of IL 8 +781 T/C is associated with the severe CDI. The presence of the IL 1 β +3953 A/G, 31 A/G and IL 8 +781 T/C genetic polymorphisms does not have a role in the development or recurrence of CDI. The second study (Clostridium difficile caused changes in FAs profile nd resolvin D1 (RvD1) content in plasma of infected patients") found that there are distinct changes in plasma FA during CDI. In the case of patients with a good outcomes, it was probably observed the effective resolution of inflamm ation, as reflected in n 3 FA metabolism and its significant decrease in relative to the control group. The third study (The level of fecal calprotectin significantly correlates with Clostridium difficile infection severity found that FC is an indication of ongoing intestinal inflammation in CDI patients. The FC levels significantly correlated with CDI severity, which shows it could prospectively serve as a predictive marker for assessing CDI severity. The ongoing search for CDI severity markers is particularly vital, enabling fast and optimal treatment approach, which is crucial in CDI therapy.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby zakaźne

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Czepiel, Jacek

Date issued:

2020

Identifier:

oai:dl.cm-uj.krakow.pl:4498

Call number:

ZB-132587

Language:

pol; eng

Access rights:

tylko w bibliotece

Subject and keywords:

Clostridium difficile diarrhoea colitis antibiotics therapy megacolon toxicum

Object collections:

Last modified:

Mar 25, 2024

In our library since:

Feb 8, 2022

Number of object content hits:

12

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4499

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Edition name Date
ZB-132587 Mar 25, 2024

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