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Title: The role of profilin 1 in ischemic heart disease

Abstract:

The aim of the study was to evaluate the role of profilin 1 (Pfn 1) in stable ischemic heart disease (SCAD) and in myocardial infarction (MI).65 MI patients and 35 with SCAD were included. In MI, a negative correlation was found between symptom duration and Pfn1 concentration, as well as between impaired reperfusion and Pfn1 concentration. A positive correlation was found between Pfn 1 concentration on admission and CK and CKMB concentrations 24 hours post revascularization. There was no correlation between Pfn1 concentration and the assessed electrocardiographic and echocardiographic parameters. Pfn 1 concentration was lower in patients with diabetes, family history of CAD and multivessel disease.The results confirm Pfn 1 may be involved in the pathogenesis of ischemic heart disease. The relationship between symptom duration and Pfn1 concentration, as well as impaired reflow after revascularization and Pfn 1 concentration may be particularly useful. In the analysis of atherosclerosis risk factors, the negative relationships between diabetes and family history of CAD and Pfn 1 are particularly important.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Krzysztof Żmudka ; Wojciech Zajdel

Date issued:

2018

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4413

Call number:

ZB-130319

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Apr 12, 2021

In our library since:

Apr 12, 2021

Number of object content hits:

1

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4414

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ZB-130319 Apr 12, 2021
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