Assessment of the prognostic value of selected markers of proliferation and angiogenesis in pituitary tumors - Digital Medical Library

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Title: Assessment of the prognostic value of selected markers of proliferation and angiogenesis in pituitary tumors

Author:

Wierzbicka-Tutka, Iga

Date:

Type:

Praca doktorska

Abstract:

Histopathology of pituitary carcinomas and locally invasive adenomas are indistinguishable from benign tumors. The aim of the study was to evaluate PTTG, PTMA, VEGF, AIP and Topo 2A as potential markers of the progression of the disease, size and local invasiveness of pituitary adenoma. The research consisted of three studies, which comprised of 55, 27 and 31 patients respectively.The Ki-67, PTTG, PTMA, VEGF, AIP, Topo 2A indices were determined by immunohistochemical staining. The relationship between markers and progression of the disease, radiological images and hormonal activity and immunohistochemistry of the tumor as well as gender and age of patients, was studied. Positive expression of Ki-67, PTTG, PTMA, VEGF, AIP and Topo2A was observed in the majority of pituitary adenomas. Besides of PTMA-n they were not related to the tumor progression. Only Ki-67, PTMA-n and Topo 2A expression correlated with tumor size. Ki-67 and Topo 2A expression was found to be related with tumor invasiveness.

Place of publishing:

Level of degree:

2 - studia doktoranckie

Degree discipline:

Degree grantor:

Wydział Lekarski

Promoter:

Gołkowski, Filip

Date issued:

Identifier:

oai:dl.cm-uj.krakow.pl:4377

Call number:

Language:

Access rights:

tylko w bibliotece

Subject and keywords:

markers of angiogenesis markers of proliferations pituitary adenoma

Object collections:

Digital Medical Library > PhD thesis database

Last modified:

Jul 6, 2022

In our library since:

Oct 5, 2020

Number of object content hits:

9

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0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4378

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Edition name	Date
ZB-128620	Jul 6, 2022

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