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Title: Conversion of L-Tryptophan to Melatonin in experimental lesions of the gastric mucosa

Abstract:

Gastritis can be induced by many factors of both endogenous and exogenous origin. The pathophysiology of this process is related to the presence of reactive oxygen species (RFT). The main factors contributing to the development of inflammatory changes in the gastric mucosa which lead to the disturbance of a delicate oxidative-anti-oxidative balance are: the reduced level of antioxidant defense involving both enzymatic and non-enzymatic mechanisms, ingestion of exogenous irritants, stress, bacterial infections and vascular disturbances related to ischemia-reperfusion phenomena (I/R). The aim of the doctoral thesis was to determine the effect of rich or L-tryptophan (L-Trp) free diet on the healing process of the experimental acetic ulcer in rats. This research attempted to study whether the abundance or lack of L-Trp, which is considered as the precursor of melatonin (MLT) biosynthetic pathway, can influence the formation and gastric tissue levels of endogenous MLT. Moreover, the biochemical pathways of melatonin, the indoleamine with a potent anti-inflammatory and antioxidative protective potentials was investigated. For this purpose, rat gastric mucosal biopsies were taken from the inflammatory sites at ulcer margin in the phase of ulcer healing. The obtained results prove that the rich L-Trp diet accelerates the process of gastric ulcer healing and inhibits the peroxidation of PUFA possibly due to the gastrointestinal conversion of L-Trp to anti-inflammatory and antioxidazing melatonin.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

biochemia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Piotr Laidler

Date issued:

2019

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4349

Call number:

ZB-130616

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Mar 3, 2021

In our library since:

Jun 26, 2020

Number of object content hits:

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4350

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ZB-130616 Mar 3, 2021
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