Object

Title: Evaluation of the usefulness of plasma renin activity determination in the selection of optimal antihypertensive therapy among patients with primary hypertension according to the Laragh and Alderman concept

Abstract:

The effectiveness of treatment of hypertension is low. The guidelines can be supplemented with "pathophysiological approach" to an individualized therapy.The objectives:-examination of the relationship between plasma renin activity (PRA), aldosterone and asymptomatic organ damage (AOD)-exploring the effect of antihypertensive treatment, consistent with Laragh and Alderman hypothesis, on blood pressure and AOD-evaluation of clinical and biochemical discrepancies among patients from low-renin and high-renin groups with particular reference to the values of serum lipidsOperating range: a planned prospective trial that included a total of 95-122 patients with first or second-degree hypertension.Conclusions:-the study of the effect of the renin-angiotensin-aldosterone system (RAAS) on the occurrence of AOD should include the relationship between the concentration of aldosterone and renin-PRA as the only indicator has no predictive value for the occurrence of AOD, on the other hand an aldosterone-to-renin ratio (ARR) does have it-the choice of antihypertensive drug based on PRA does not determine either the magnitude of the blood pressure reduction nor thesignificance of the AOD regression-patients with high-renin hypertension are characterized by higher serum total cholesterol and LDL-cholesterol, but the relationship between LDL-cholesterol and PRA is only in the low-renin group.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Marek Rajzer

Date issued:

2018

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4344

Call number:

ZB-130875

Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Jun 23, 2020

In our library since:

Jun 23, 2020

Number of object content hits:

5

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4345

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Edition name Date
ZB-130875 Jun 23, 2020

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