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Title: Determination of metabolic brain model in children using proton magnetic resonance spectroscopy (1H MRS)

Abstract:

The aim of the study was to determine the metabolic model of the brain in children (6 to 15-year-old) using proton magnetic resonance spectroscopy (1H MRS). Particular attention was paid to the occurrence of the brain metabolic composition differences between girls and boys, between selected brain regions and between the brain hemispheres in children, as well as differences resulting from the stage of development (fetuses and children). Absolute and relative concentrations of metabolites in the brain (frontal lobes, basal ganglia, hippocampus, cerebellum) of healthy children and fetuses were computed: N-acetylaspartate (NAA), creatine (Cr), choline (Cho), myo-inositol (mI), lipids (Lip) and lactates (Lac).On the basis of the studies and analyzes, it was possible to determine the metabolic model and to state that: •the child's brain shows only a few sex differences in the biochemical composition; •the child's brain is inhomogeneous and characterized by regional variability of the biochemical composition within each hemisphere; •the child's brain, without sex distinction, is characterized by a lack of significant biochemical lateralization; •the brain undergoes significant changes in the biochemical composition from fetal to childhood.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

radiologia ; neurologia ; pediatria

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Andrzej Urbanik

Date issued:

2018

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4339

Call number:

ZB-130897

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Mar 12, 2021

In our library since:

Jun 22, 2020

Number of object content hits:

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4340

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ZB-130897 Mar 12, 2021
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