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This publication is protected and can be accessed only from certain IPs.

Title: Development of a panel of protein biomarkers and their application to multi-parameter assessment of vascular endothelial function

Author:

Suraj-Prażmowska, Joanna

Date:

2019

Type:

Praca doktorska

Abstract:

Healthy endothelium is essential for the proper functioning of the cardiovascular system, and its dysfunction is the cause or the consequence of many diseases. The aim of the study was to develop and validate the method for simultaneous determination of a panel of endothelial specific protein biomarkers using targeted proteomics. Furthermore, the goal was to assess the changes in biomarker concentrations in the diseases with confirmed endothelial dysfunction in mouse models of fatty liver caused by high-fat diet, endotoxemia induced by intraperitoneal administration of lipopolysaccharide and metastatic breast cancer. The developed methodology was also used to determine the plasma biomarker concentrations of healthy volunteers, patients with chronic myeloid leukemia treated with imatinib and patients with obstructive sleep apnea. The developed panel included markers involved in processes specific for glycocalyx disruption, endothelial inflammation, increased vascular permeability, dysregulation of hemostasis and other processes related to endothelial dysfunction. The elaborated targeted proteomic method for determination of selected mediators released by the vascular endothelium has the potential to be used in humans as a new tool in the early diagnosis of diseases with confirmed vascular endothelial dysfunction and to monitor the effectiveness of the therapy.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia ; farmacja

Degree grantor:

Wydział Farmaceutyczny

Promoter:

Walczak, Maria ; Kurpińska, Anna

Date issued:

2019

Identifier:

oai:dl.cm-uj.krakow.pl:4326

Call number:

ZB-131397

Language:

pol; eng

Access rights:

tylko w bibliotece

Subject and keywords:

biomarkers mouse models of civilization diseases endothelium mass spectrometry microLC/MS-MRM method

Object collections:

Last modified:

Mar 13, 2023

In our library since:

Jun 17, 2020

Number of object content hits:

7

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4327

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Edition name Date
ZB-131397 Mar 13, 2023

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