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This publication is protected and can be accessed only from certain IPs.

Title: Evaluation of the safety profile of biological drugs used in the treatment of inflammatory bowel diseases

Author:

Moćko, Paweł

Date:

2018

Type:

Praca doktorska

Abstract:

Introduction: Ulcerative colitis (UC) and Crohn disease (CD) are classified as nonspecific inflammatory bowel diseases (IBDs). The aim of the study was to compare the safety profile of biologic drugs in patients with IBDs.Methods: A systematic literature search was performed using PubMed, Embase, and CENTRAL. Randomized controlled trials comparing biologic drugs used in the treatment of patients with UC (infliximab, adalimumab, golimumab, and wedolizumab) or CD (infliximab, adalimumab, wedolizumab, certolizumab pegol, and ustekinumab) with placebo were analyzed. The safety profile of biologic drugs was assessed using a network meta-analysis (NMA). The NMA was performed separately for patients with UC and CD, and generally for patients with IBDs. The study was registered on PROSPERO (CRD42016032607, CRD42016032606, CRD42015029884).Results: For most comparisons and endpoints, the NMA showed no significant differences in the rate of adverse events. A significantly higher risk of injection site reaction was showed for adalimumab compared with placebo (patients with UC) and a significant advantage of certolizumab pegol over infliximab and placebo (patients with IBDs). Conclusion: There were no significant differences in the relative assessment of these drugs or in their safety profile, as compared with placebo.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu trawiennego

Degree grantor:

Wydział Nauk o Zdrowiu

Promoter:

Pilc, Andrzej ; Kawalec, Paweł

Date issued:

2017

Identifier:

oai:dl.cm-uj.krakow.pl:4290

Call number:

ZB-128494

Language:

pol; eng

Access rights:

tylko w bibliotece

Subject and keywords:

ulcerative colitis biologic drugs Crohn disease network meta-analysis safety profile

Object collections:

Last modified:

Mar 17, 2023

In our library since:

May 29, 2019

Number of object content hits:

55

Number of object content views in PDF format

1

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4291

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Edition name Date
ZB-128494 Mar 17, 2023

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