Advanced search ?

Object

Prospects of pharmacological action of lipoic acid in the aspect of its new potential biological activity

Download

Title: Prospects of pharmacological action of lipoic acid in the aspect of its new potential biological activity

Author:

Bilska-Wilkosz, Anna

Date:

2018

Type:

Praca doktorska

Abstract:

Lipoic acid (LA) is a drug with proven effect on pathogenetic mechanisms of diabetic polyneuropathy. Recent studies have indicated that LA can also be useful in the treatment of other disorders, including cardiologic, neurological, dermatologic and even oncologic diseases. However, the mechanism of so wide spectrum of pharmacological activities of LA is still insufficiently known. The aim of the present study was to broaden our knowledge of the mechanisms of biological action of LA delivered from exogenous sources. One of difficulties in studying the mechanisms of pharmacological action of LA is related to the fact that the effects of its action in vitro can differ from those observed in vivo. Nonetheless, in spite of many questions that still remain unanswered, the results of the present study unequivocally indicate that one of the mechanisms underlying biological activity of LA involves its participation in metabolic transformation of sulfane sulfur and hydrogen sulfide, defined as reactive sulfur species (RSS). It should be remembered that multidirectional regulatory functions of RSS are manifested mostly by changing the activity of many enzymatic and receptor proteins. Therefore, the hypothesis explaining LA efficacy in so many often remote pathological states by its effect on RSS transformations seems reliable and logically coherent.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmacja

Degree grantor:

Wydział Farmaceutyczny

Promoter:

Włodek, Lidia

Date issued:

2017

Identifier:

oai:dl.cm-uj.krakow.pl:4287

Call number:

ZB-128501

Language:

pol; eng

Access rights:

nieograniczony

Subject and keywords:

lipoic acid potassium cyanide aldehyde dehydrogenase sulfane sulfur hydrogen sulfide

Object collections:

Last modified:

Jun 26, 2023

In our library since:

May 29, 2019

Number of object content hits:

263

Number of object content views in PDF format

188

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4288

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-128501 Jun 26, 2023

Objects

Similar

Prospects of pharmacological action of lipoic acid in the aspect of its new potential biological activity

Bilska-Wilkosz, Anna

2018
Praca doktorska

Effect of cocaine on the metabolism of endogenous sulfur compounds in rats

Kowalczyk-Pachel, Danuta

2022
Praca doktorska

Study of the activity and expression of the enzymes involved in the formation of hydrogen sulfide in various experimental systems

Bronowicka-Adamska, Patrycja

2017
Praca doktorska

The influence of the lipoic acid on the tolerance to nitroglycerin in in vivo and in vitro studies

Kotańska, Magdalena

2009
Praca doktorska

Anaerobic metabolism of sulfur in selected tissues of animalsexposed to lead, cadmium and mercury ions

Kaczor-Kamińska, Marta

2015
Praca doktorska

Study of the effect of hypertension and age on the formation of hydrogen sulfide and nitric oxide in selected rat tissues

Szlęzak, Dominika

2023
Praca doktorska

Importance of sulfane sulfur and S-thiolation reactions for modulation of biological activity of thiols

Iciek, Małgorzata

2007
Praca doktorska

The effect of cysteine desulfuration on the proliferation of normal and neoplastic brain cells

Jurkowska, Halina

2008
Praca doktorska
More
×

Citation

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

This page uses 'cookies'. More information