Title: Erectile dysfunction in patients with coronary heart disease treated by percutaneous coronary intervention


Objectives (end points):1. To determine the effectiveness and safety of erectile dysfunction (ED) treatment with sildenafil citrate in patients with stable ischemic heart disease, treated by PCI.2. To determine the improvement of ED after PCI itself.3. To determine the change in QoL induced by both PCI and the following sildenafil citrate ED pharmacotherapy.Methods:The study was prospective, randomized, double blinded and placebo controlled. 51 men were included.The improvement in ED was assessed by the use of the IIEF-5 questionnaire, the Quality of Erection Questionnaire (QEQ) and partially by the Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) questionnaire.The safety and tolerability of sildenafil citrate therapy was established by adverse events self-reports, basic clinical tests (blood pressure, rest electrocardiography), treadmill stress test (Bruce protocol), laboratory tests and EDITS questionnaire.The change in the quality of life was assessed by the use of the Euro-QoL (EQ-5D) questionnaire.Results:There was statistically significant difference between placebo and sildenafil arm according to ED (p < 0,01) and QoL (p < 0,01) improvement .During the trial there was no significant adverse effects reported.PCI itself caused an improvement in ED (p < 0,01) and QoL (p < 0,01).

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Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia ; urologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.


Leszek Bryniarski

Date issued:



oai:dl.cm-uj.krakow.pl:4258 ; ZB-129252


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Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

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Last modified:

May 24, 2021

In our library since:

Apr 11, 2019

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Edition name Date
ZB-129252 May 24, 2021


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