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Title: Mobilization of stem cells into the peripheral blood in children with congenital heart disease

Abstract:

Congenital heart defects (CHDs) are observed in about 0.8% to 1.0% of live-born new-borns. Owing to advances in prenatal diagnosis, prenatal care, and surgical treatment of CHDs, the prognosis of this population has vastly improved. Despite the satisfactory quality of life after a surgical repair, a considerable percentage of these patients develop symptoms of heart failure in a long-term follow-up. The treatment options in this group are limited. Stem cell research has opened up the possibility to use stem cells in the treatment of end-stage heart failure.It was demonstrated that: ; 1. In children with CHDs, the mobilization of various types of stem and progenitor cells to peripheral blood is observed. 
2. The level of mobilization of stem cell is correlated with individual factors (patient age), factors associated with the pathophysiological features of the defect (hypoxia, pressure overload, volume overload), and factors associated with an acute stress response to a surgery. 
3. The mobilization of stem cell is modulated by perioperative factors such as the duration of extracorporeal circulation, the duration of aortic clamping, and the use of medications (nitric oxide, catecholamines). 
4. The stimulated regenerative mechanisms may be regulated pharmacologically and their potential may be used in the early postoperative period (modulation of stress response, stimulation of regeneration and restoration of heart function) as well as in the long-term postoperative period. 


Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

pediatria ; kardiochirurgia ; choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Jacek Kołcz

Date issued:

2017

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4251

Call number:

ZB-127768

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

May 24, 2021

In our library since:

Aug 28, 2018

Number of object content hits:

23

Number of object content views in PDF format

11

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4252

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Edition name Date
ZB-127768 May 24, 2021

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