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Title: Anti-retinal antibodies in sera from patients with diabetic retinopathy

Author:

Węglarz, Monika

Date:

2017

Type:

Praca doktorska

Abstract:

The aim of the study was to enrich the knowledge about the role of autoantibody-related autoimmunity in the evolution of diabetic retinopathy (DR). The occurrence of retina specific autoantibodies in sera from patients with DR and their association with patients’ clinical characteristics were evaluated. With the use of indirect immunofluorescence the presence and levels of anti-retinal antibodies (ARA) in 61 sera from patients with different stages of DR and 30 sera from age-matched controls were examined. The highest incidence and intensity of immunofluorescence was noted in the layer of the photoreceptor outer segments. The incidence and sera levels of ARA were changing depending on the stage of DR and depending on the presence of clinical features of DR such as cystoid macular oedema (CMO), neovascularization of the retina (NVE), attributes of preproliferative retinopathy and symptoms of extreme retinal ischemia (diagnosed on the basis of extensive fibrovascular proliferation of the optic disc and neovascularization of the iris accompanied by broad capillary nonperfusion areas within the whole retina in fluoroangiography, and the lack of CMO and NVE in both eyes). The results of the study suggest that autoantibody-related autoimmune response may be an important factor of the photoreceptor damage in the pathogenesis of DR.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

okulistyka

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Bożena Romanowska-Dixon

Date issued:

2017

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4247

Call number:

ZB-127769

ControlNumberVIRTUA:

click here to follow the link

Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Subject and keywords:

anti-retinal antibodies diabetic retinopathy retinal autoimmunity indirect immunofluorescence

Object collections:

Last modified:

Aug 27, 2018

In our library since:

Aug 27, 2018

Number of object content hits:

15

Number of object content views in PDF format

4

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4248

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Edition name Date
ZB-127769 Aug 27, 2018

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