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Title: The mechanisms and the role of oxidative stress in the bronchial wall in a model of asthma and bronchial hyperreactivity

Abstract:

The diagnosis and treatment of asthma is a significant problem of public health. Among the triggers of bronchial hyperreactivity, oxidative stress appears to play a vital role. Therefore, it was justified to undertake research into the mechanisms and the functional role of oxidative stress in the bronchi in a model of bronchial hyperreactivity. Towards this end, an experimental model of asthma was created using Dunkin Hartley guinea pigs. In a series of experiments, segments of the animals’ superior and medial lobar bronchi were exposed to: acetylocholine, histamine, MnTBAP (“scavenger” of free radicals) and DETC. Bronchial hyperreactivity was tested using an organ bath. The parameters of oxidative stress were assessed through the measurement of superoxide radical anion (O2-.) production in the bronchial segments using chemiluminescence. The results indicate a significant role of non-specific reactions in the occurrence of bronchospasm, which confirms the complex pathophysiology of bronchial hyperreactivity.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

pulmonologia ; alergologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Tomasz Guzik

Date issued:

2017

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4244

Call number:

ZB-128095

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

May 24, 2021

In our library since:

May 10, 2018

Number of object content hits:

27

Number of object content views in PDF format

16

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4245

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ZB-128095 May 24, 2021
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