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Title: Construction and testing of a novel original apparatus for testing biologically active substances release from some drugs and foodstuffs

Abstract:

The main goal of this dissertation was building of a new apparatus using a syringe pump, meant for dissolution testing in a flow through manner, applicable to both drugs and food/dietary special. Furthermore a novel application of voltammetric method was used for determination of analytes in dissolution media, a method that is rarely used in dissolution testing at all.Due to constructing a novel apparatus three basic parts were designed, a simple syringe pump a low-volume dissolution chamber allowing flow in both direction and a stepper motor driver. The syringe pump was designed as six route one. As the drive source stepper motor with was used. The stepper motor was driven with a microstep driver connected to a PC by a LPT port. The software used for controlling the pump was Linux CNC.The verification of apparatus was done using prednisolone and izoniazide dissolution a variety of herbs, dietary special and foods was also examined. Apart from herbs, dietary special were also used: capsules Swanson full spectrum Bacopa moniera 500 mg, 90 caps. and Spirulina powder bio Spirulina obtained from powdered algae. Foodstuffs were also used – boletus badius mycelcial cultures were also applied with addition of toxic elements, cadmium and lead.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmacja

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Farmaceutyczny.

Promoter:

Włodzimierz Opoka

Date issued:

2017

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4236

Call number:

ZB-128008

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

May 24, 2021

In our library since:

Mar 29, 2018

Number of object content hits:

14

Number of object content views in PDF format

4

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4237

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ZB-128008 May 24, 2021
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