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Title: Evaluation of anti-inflammatory activity of extracts fromselected species of edible mushrooms and their biomass usingmolecular biology techniques.

Abstract:

The inflammation, which is a response of tissuesto damaging agents is a natural adaptive process in thehuman body. However, chronic inflammatory process canbe associated with the pathogenesis of cardiovasculardisease, cancer and metabolic syndrome.The purpose of this research aims to determinedpotential anti-inflammatory properties of biomass extractsfrom in vitro cultures of selected edible mushrooms:Imleria badia − bay bolete, Cantharellus cibarius − goldenchanterelle and Agaricus bisporus − white bottommushroom. These popular mushroom species are a richsource of phenolic and indole compounds, unsaturated fattyacids and bioelements with anti-inflammatory activity.To investigate the anti-inflammatory effect of the testedextracts several cell lines: RAW 264.7, A549 and CaCo-2were used. The effects of mushroom extracts on theexpression of inflammatory markers, such ascyclooxygenase-2 (COX-2), prostaglandin E (cPGES),glutathione S-transferase (GSTM1), FP-receptor protein,interleukin-6 (IL-6), and transcriptional factors PPARγ,NF-ĸB and Nrf2 were analyzed.The tested extracts showed anti-inflammatory activityin the used in vitro models. Received results showedsignificant inhibition of inflammatory markers caused bytested extracts from I. badia, C. cibarius and A. bisporusand also a stimulatory effect on the nuclear factor Nrf2-dependent detoxification processes. Additionally, obtainedresults showed the importance of zinc and α-linolenic acidduring inflammatory processes in tested cell lines.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

botanika ; farmakologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Farmaceutyczny. Katedra i Zakład Botaniki Farmaceutycznej.

Promoter:

Bożena Muszyńska ; Joanna Gdula-Argasińska

Date issued:

2017

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4234

Call number:

ZB-127561

ControlNumberVIRTUA:

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Language:

pol ; eng

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

May 24, 2021

In our library since:

Mar 20, 2018

Number of object content hits:

23

Number of object content views in PDF format

12

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4235

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ZB-127561 May 24, 2021
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