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Title: Influence of zinc ions on the activity of non-steroidal anti-inflammatory drugs (NSAIDs)

Abstract:

The anti-inflammatory, antioxidant and gastroprotective properties of zinc have been documented by a number of studies, but their clinical use is still limited. At the same time, extensive searches for new, more effective and safer anti-inflammatory drugs are being conducted. The aim of the study was to evaluate the effect of zinc ions on the anti inflammatory activity of ketoprofen, ibuprofen and naproxen, while assessing gastric mucosal irritation after acute and chronic administration of zinc hydroaspartate along with NSAIDs, as well as synthesized complexes of Zn-ibuprofen and Zn-naproxen. The results of the study confirmed the anti inflammatory properties of zinc ions and the validity of their preventive supplementation in the course of inflammatory processes and during NSAID treatment. The protective effect of zinc on gastric mucosa after ketoprofen, ibuprofen and naproxen was also demonstrated. In view of the above results, zinc supplementation during NSAID therapy may allow for the reduction of the effective dose of the parent drug thereby limiting its gastrointestinal side effects.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmakologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Farmaceutyczny. Katedra Farmakobiologii. Zakład Radioligandów.

Promoter:

Tadeusz Librowski ; Katarzyna Młyniec

Date issued:

2017

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4213

Call number:

ZB-127776

ControlNumberVIRTUA:

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Language:

pol ; eng

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Mar 15, 2018

In our library since:

Mar 15, 2018

Number of object content hits:

9

Number of object content views in PDF format

9

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4214

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ZB-127776 Mar 15, 2018
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