Object

This publication is protected and available only for logged users.
This publication is protected and available only for logged users.

Title: Evaluation of psychotropic activity of selected indoleamine derivatives with multireceptor profile of action

Abstract:

Dissertation presents findings of pharmacological in vitro and in vivo studies evaluating psychotropic activity of 7 differently substituted indole derivatives. The other aim of this study was the attempt to clarify mechanism of their potential central activity, especially for ADN-2013. Aripiprazole was used as a reference atypical antipsychotic drug.In pharmacological studies in vitro, monoaminergic receptor binding profile and functional activity have been determined toward receptors D2, D3, 5-HT1A, 5-HT2A, 5-HT6, 5-HT7, α1, M and other binding sites e.g. SERT, hERG. In order to verify potential antipsychotic and cataleptogenic activity– the locomotor hyperactivity induced by D-amphetamine and MK-801 and the bar test, respectively, in mice, antidepressant activity – the forced swim test in mice and rats and the tail suspension test in mice, anxiolytic activity– the four-plate and marble burying tests in mice as well as the conflict drinking Vogel and the elevated plus-maze tests in rats were performed. Moreover, a mutagenic activity in vitro and an anorectic effect in vivo have been studied for ADN-2013. The specificity of each effect has been confirmed by appropriate control tests.The results of pharmacological studies presented confirm the desirability of searching for compounds with a multi-receptor profile of activity. ADN-2013 has been selected as a lead structure for further research focusing on the search for more effective and safer drugs that can be used in therapy of behavioural and psychological symptoms of dementia.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmacja

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum.

Promoter:

Anna Wesołowska ; Marcin Kołaczkowski

Date issued:

2017

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4210

Call number:

ZB-127560

ControlNumberVIRTUA:

click here to follow the link

Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Mar 15, 2018

In our library since:

Mar 15, 2018

Number of object content hits:

5

Number of object content views in PDF format

5

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4211

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-127560 Mar 15, 2018
×

Citation

Citation style:

This page uses 'cookies'. More information