Object

This publication is protected and available only for logged users.
This publication is protected and available only for logged users.

Title: Eicosanoids measured in induced sputum and asthma phenotypes

Abstract:

Introduction: Asthma is currently considered in terms of phenotypes, rather than of a single respiratory disease. Profiling eicosanoids in induced sputum (IS) with the means of sensitive analytical methods provides detailed information on asthmatic inflammation.Objective: In order to investigate interactions between airway inflammation and phenotypes of asthma, we integrated clinical data, IS eicosanoids and quantitative assessment of infiltrating cells into new subtypes of asthma with the means of latent class analysis (LCA).Methods: Groups of 75 AERD, 64 with aspirin-tolerant asthma (ATA) subjects and 37 healthy controls (HC) were enrolled into the study. All of them underwent sputum induction. High-performance liquid chromatography or gas chromatography coupled with mass spectrometry were used to profile eicosanoids in induced sputum supernatant (ISS).Results: Four phenotypic asthma classes were distinguished. Representing disease spectrum from mild to moderate allergic asthma with low sputum eosinophilia to severe asthma with impaired lung function, chronic rhinosinusitis, eosinophilic and neutrophilic inflammation and frequent aspirin hypersensitivity. Increased levels of lipid mediators were measured: PGA2 in class 1, cys-LTs and PGD2 in class 2 and in PGE2 in class 4. Aspirin hypersensitivity was most frequent in class 2, but also present in class 1 and 4.Conclusions: Eosinophils and their mediators: cys-LTs and PGD2 were identified to have special importance in the pathophisiology of severe asthma phenotypes. This study points out the heterogenity of AERD population.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

pulmonologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Lucyna Mastalerz

Date issued:

2016

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4204

Call number:

ZB-127028

ControlNumberVIRTUA:

click here to follow the link

Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

May 24, 2021

In our library since:

Nov 7, 2017

Number of object content hits:

12

Number of object content views in PDF format

12

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4205

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-127028 May 24, 2021
×

Citation

Citation style:

This page uses 'cookies'. More information