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Title: Studies on the significance of serum ferritin concentration in Gaucherdisease, hemophagocytic lymphohistiocytosis and before allogeneicstem cell transplantation

Author:

Lorenz, Fryderyk

Date:

2017

Type:

Praca doktorska

Abstract:

The aim of the first study was to determine the effect of pretransplantationhyperferritinemia on survival, graft versus host disease(GVHD). It was found that hyperferritinemia was associated withdecreased frequency of chronic GVHD, shorter survival and higherrisk of relapse. In the second survey we evaluated sigificance ofhyperferritinemia in patients with Gaucher disease (GD1). Studyshowed elevated ferritin levels in the majority of patients There wasno correlation between hyperferritinemia and the clinical status. sIL-2Rα was relatively low. TNF-α was moderately elevated.Hiperferritinemia improved and TNF-α normalized in all treatedpatients. In the third study we analyzed significance ofhiperferritinemia in the malignancy associated hemophagocyticlymphohistiocytosis (M-HLH). We have found elevated ferritin,cytokine and sIL-2Rα levels. Based on the existing literature data aswell as on the results presented in the submitted thesis, it can beassumed that ferritin can be used as a prognostic biomarker in patientstreated with alloSCT and as a marker of treatment response in patientswith GD1. Level od ferritinemia had no prognostic significance inpatients with M-HLH.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

hematologia

Degree grantor:

Wydział Lekarski

Promoter:

Skotnicki, Aleksander ; Machaczka, Maciej

Date issued:

2017

Identifier:

oai:dl.cm-uj.krakow.pl:4202

Call number:

ZB-127027

Language:

pol; eng

Access rights:

tylko w bibliotece

Subject and keywords:

hyperferritinemia cytokines allogeneic stem cell transplantation Gaucher disease hemophagocytic lymphohistiocytosis

Object collections:

Last modified:

Mar 14, 2023

In our library since:

Nov 7, 2017

Number of object content hits:

136

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4203

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Edition name Date
ZB-127027 Mar 14, 2023

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