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Title: Evaluation of the microbial flora of the large intestine in adults with type 1 and type 2 diabetes

Abstract:

The aim of this study was a qualitative and quantitative assessment of the composition of the colon microbial flora in patients with type 1 and type 2 diabetes as well as in healthy subjects and an attempt to establish a connection in people with diabetes of data obtained from the microbiological examination with clinical data.Stool samples from people with diabetes and healthy people (control group) were used to achieve the above assumptions. With one of theNGS methods (sequencing by synthesis), using the MiSeq sequencer (Illumina), the presence of a total of 1,021 operational taxonomic units (OTUs) has been demonstrated, of which have not yet been named.At the taxonomic level L6 (Genus), statistically significant differences were showed in the profile of bacteria that tend to indicate that the gut microbiota of people with type 2 diabetes is considerably different from the microflora of the large intestine in the control group and from the group with type 1 diabetes. When analyzing beta diversity, there was a greater phylogenic relationship between microorganisms in the control group compared to the group of people with diabetes, both type 1 and type 2.In the analysis of the above results of microbiological tests with clinical data of patients with diabetes, a correlation has been established between several types of microorganisms (including bacteria belonging to the genus Faecalibacterium) with the percentage of glycated hemoglobin in people with type 2 diabetes, as well as a correlation of bacteria belonging to the genus Bifidobacterium with the concentration of HDL cholesterol in patients with both type 1 and type 2 diabetes.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

mikrobiologia ; endokrynologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Małgorzata Bulanda

Date issued:

2016

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4177

Call number:

ZB-126490

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

May 24, 2021

In our library since:

Jun 28, 2017

Number of object content hits:

21

Number of object content views in PDF format

21

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4178

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ZB-126490 May 24, 2021
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