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Title: Activation of .blood coagulation and fibrynolysis in bronchial asthma

Abstract:

This controlled study analysed thrombin generation, fibrinolysis and platelet activation in patients with allergic and non allergic asthma.164 asthmatics were compared to 72 healthy volunteer control group matched for age, sex, and BMI. Asthmatics had an altered thrombin generation profile, peak thrombin elevated by 41,5%, endogenous thrombin potential by 20.1%, (p<0.0001), faster thrombin formation: 15.5% shorter time to maximum, 11% shorter lag phase, respectively in asthmatics compared with controls. Asthmatics had impaired fibrinolysis: 14.4% longer clot lysis time, (p= 0.001), higher plasminogen, plasminogen activator inhibitor-1, (p<0.0001), endogenous thrombin potential, peak thrombin concentration, maximal prothrombin conversion rate (4.2%, 21.3%, 20.2%, 41.4%, 61%, respectively), 15.5% faster rate of thrombin formation, 10% lower thrombin decay capacity (all, p<0.0001) compared to controls. Asthmatics had 14.5% higher α2-macroglobulin, 5.6% lower antithrombin, unaltered prothrombin. α2-macroglobulin correlated positively with prothrombin (r=0.27, p<0.01) in allergic asthma. Non-allergic asthmatics (n=70, 42.6 %) had 17.5% longer CLT (p=0.02), which positively correlated with PAI-1 (r=0.19, p=0.049). Thrombin generation profile was not affected by allergy. α2-macroglobulin correlated positively with prothrombin (r=0.27, p<0.01) in allergic asthma. Serum PF4, but not P-selectine was 51% higher (p<0.0001) in asthmatics. The blood CD62P value did not differ in asthmatics and healthy controls. Allergic asthmatics (n=107) did not differ from non allergic asthmatics.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

pulmonologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Lucyna Mastalerz

Date issued:

2016

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4168

Call number:

ZB-126418

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

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Last modified:

Jun 26, 2017

In our library since:

Jun 26, 2017

Number of object content hits:

5

Number of object content views in PDF format

5

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4169

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ZB-126418 Jun 26, 2017
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