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Title: The significance of selected polymorphisms in the promoter region of the gene for tumor necrosis factor alpha in the development and course of acne

Abstract:

Introduction: Etiopathogenic mechanisms of acne have been studied for years. Gaps in knowledge on acne pathophysiology constitute a significant therapeutic problem. Available treatments are not fully efficient, especially in the case of patients with severe acne.Aims of the study:To explain the role of selected polymorphisms of the tumor necrosis factor alpha promoter gene in the development of acne vulgaris.To analyze an association between the family history of acne, presence of this condition and type of its onset in the studied patients.Methods: The study included 97 individuals aged 18-30 years. Two samples of the blood were obtained from the study subjects to determine their TNF-α promoter gene polymorphisms at positions -308 and -857, and to measure their serum concentrations of TNF-α.Conclusions: The hereby presented findings imply that the TNF-α promoter gene polymorphisms at positions -308 and -857 may play a role in the development of acne. Patients with acne and healthy controls did not differ significantly in terms of their serum concentrations of TNF-α. Both our hereby presented findings and previously published clinical data suggest that TNF-α plays an important role in the pathogenesis of acne vulgaris.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

dermatologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Anna Wojas-Pelc

Date issued:

2016

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4166

Call number:

ZB-126421

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

May 24, 2021

In our library since:

Jun 19, 2017

Number of object content hits:

7

Number of object content views in PDF format

7

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4166

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ZB-126421 May 24, 2021
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