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Title: Th17/T-regulatory lymphocytes axis in systemic lupus erythematosus

Abstract:

Systemic lupus erythematosus (SLE) is an autoimmune disease with complex ethiopathology. Disorder of autoregulation of the immune system underlies SLE pathology. Th17 cells participation in development of SLE and protective activity of Treg cells has been proven. Nevertheless, there are not clear research data concerning the relationship between Treg cells and Th17 cells and cytokines participating in autoagressive diseases such as SLE. The aim of this project was to evaluate of function and quantitative changes of T regulatory cells and Th17 effector cells and cytokines such as IL-10, TGF-β1 and IL-17. Moreover a relationship between suppressor T lymphocytes and effector T cells (axis of lymphocytes between Treg and Th17) in SLE flare was evaluated. 26 patients with SLE were qualified for the study and divided into a group with SLE flare (SLEDAI > 5 points) and in remission. Collected lymphocytes from venous blood were evaluated by flow cytometry, cytokines were analyzed in ELISA tests.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

immunologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Jacek Musiał

Date issued:

2016

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4155

Call number:

ZB-126043

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

May 24, 2021

In our library since:

Mar 23, 2017

Number of object content hits:

7

Number of object content views in PDF format

7

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4155

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ZB-126043 May 24, 2021
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