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Title: The effect of type 2 diabetes on HDL-cholesterol oxidative stress profile in patients with ischemic heart disease

Abstract:

Recent observational studies have confirmed that the atheroprotective activity of properly functioning HDL-C is frequently impaired in clinical situations associated with oxidative stress like diabetes type 2 (T2D). The objective of this study was to analyze the effect of T2D on apolipoprotein A-I (ApoA-I) and apolipoprotein A-II (ApoA-II), hsCRP, oxidative stress markers (MDA, 8-iso-PGF2α, and Ox-LDL), and enzymes that modify HDL-C function (MPO and PON-1) in patients with ischemic heart disease (IHD). An observational cross-sectional study was conducted. Patients were recruited to two study groups. In total, the study included 70 patients, 35 of whom had IHD with T2D, and 35 had IHD without T2D. Data on demographic characteristics, physical activity, diet, smoking status, concomitant diseases, and current medications were collected from each patient. The quantities of ApoA-I, ApoA-II, Ox-LDL, MDA, 8-iso-PGF2α, MPO, PON-1, hsCRP were measured. The study revealed no significant differences in the serum levels of ApoA-I and ApoA-II, hsCRP, and oxidative stress markers between the groups. However, it revealed a significant difference in the serum levels of the enzymes between the groups. Our results showed increased MPO levels in diabetes patients. The analysis also revealed that T2D is independently associated with an increase in MPO levels. Simultaneously, a decrease in PON-1 levels was observed in patients with T2D. The study also revealed that T2D is independently associated with a decrease in PON-1 levels. Finally, we revealed a positive correlation between the levels of TG and those of Ox-LDL and 8-iso-PGF2α.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Adam Windak

Date issued:

2016

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4147

Call number:

ZB-126047

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

May 24, 2021

In our library since:

Mar 14, 2017

Number of object content hits:

8

Number of object content views in PDF format

8

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4147

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ZB-126047 May 24, 2021
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