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Title: Immuno – inflammatory response, clinical outcome and early prognosis in acute myocardial infarction
Abstract:
Ischemic heart disease remains the main cause of mortality in developed countries. In recent decades the role of immune and inflammatory reactions has been proved in plaque formation and destabilization leading to acute coronary syndrome. Heart failure develops mainly due to ischemic process. In present study I verified the hypothesis that exacerbation of immune-inflammatory mediators activity is related to left ventricular failure and early prognosis after myocardial infarction. Men aged 45-60yrs were assigned to 3 groups: ACS – in 2nd day of acute myocardial infarction; SCAD – with stable coronary artery disease; control – with no history of ischemic disease. Chosen biochemical immune-inflammatory and echocardiographic left ventricular function parameters as well as clinical manifestation during ACS and after 3 months were compared. There have been higher concentrations of IgE (p=0.031) and inflammatory markers: WBC, hs-CRP, IL-6 in ACS group (p<0.001 for all). At 3months levels of all immune and inflammatory factors decreased significantly (p=0.002 for TNFα; p<0.001 for others). In ACS and at 3months levels of NT pro-BNP correlated with concentrations of IL-6 (p<0.05) and hs-CRP (p=0.004). At 3 months the relation of IL-6 and hs-CRP with left ventricular function parameters was observed - LVEDV, LVEDVI (p<0.05 and p<0.02 for IL-6 and hs-CRP respectively) and LVSV (p<0.01 for ; hs-CRP). 2nd day IL-6 concentrations were also correlated with NT pro-BNP levels at 3 months (p=0.049). These data suggests collaboration of immune and inflammatory factors in heart failure development.
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Last modified:
Mar 16, 2023
In our library since:
Mar 14, 2017
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10
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All available object's versions:
http://dl.cm-uj.krakow.pl:8080/publication/4146
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| Edition name | Date |
|---|---|
| ZB-125996 | Mar 16, 2023 |
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