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Title: Detection of early relapse with flow cytometry and its impact on effectiveness of pre-emptive treatment in patients with mantle cell lymphoma

Author:

Krawczyk, Katarzyna

Date:

2016

Type:

Praca doktorska

Abstract:

The analysis of 226 patients, treated with MCL in Hematology Clinic UJCM between 1992-2013, was conducted. 1st line chemotherapy regimens were: CHOP +/- R in 50%, FC+/-R in 23% and intensive induction treatment with cytarabine in 20%. Consolidation with radioimmunotherapy was administered in 34 cases, in 47 – HDT/ASCT. MRD was regularly assessed with flow cytometry in 46 patients. In 75% molecular was detected. Pre-emptive treatment was conducted in 25 cases. 20 of these patients, were treated intensively in the first line, with HDT/ASCT consolidation. Fist line treatment results were: ORR in 71,68%, SD in 5,31%. MCL was refractory in 24,78 % of cases. Median PFS was 28,78 months and median OS 49,9. Treatment results were similar to data from multicenter trials. Survival depended on: type of 1st line treatment and risk factors – MPI. MRD follow-up with flow cytometry is effective in molecular relapse detection, its implementation has an impact on survival in MCL patients. Pre-emptive therapy is effective method of MRD (-) re-achieving (ORR 80%). The use of pre-emptive therapy has a strong impact on OS and PFS among MCL patients, especially in subgroup after consolidation with HDT/ASCT (5-cio letnie OS 100%, vs.65%, PFS 100% vs.45%).

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

hematologia

Degree grantor:

Wydział Lekarski

Promoter:

Jurczak, Wojciech

Date issued:

2016

Identifier:

oai:dl.cm-uj.krakow.pl:4111

Call number:

ZB-124961

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

minimal residual disease mantle cell lymphoma molecular relapse pre-emptive therapy

Object collections:

Last modified:

Mar 16, 2023

In our library since:

Aug 24, 2016

Number of object content hits:

13

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4111

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Edition name Date
ZB-124961 Mar 16, 2023

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