Object

This publication is protected and available only for logged users.
This publication is protected and available only for logged users.

Title: The incidence of stroke, thromboembolic events and bleeding after left atrial appendage closure in atrial fibrillation patients with high CHADS2-score, CHA2DS2-VAS-score and HAS-BLED

Abstract:

Stroke and systemic thromboembolism are the most feared complications of atrial fibrillation (AF). The main source of thrombus in AF is left atrial appendage (LAA). Oral anticoagulation (OAC) therapy is the most effective prophylactic approach to reduce thromboembolic risk. However, there is a large number of patients in whom OAC is ineffective or contraindicated. For those patients, percutaneous LAA ligation may be an alternative treatment.Percutaneous epicardial LAA suture ligation with LARIAT is one of the most widely used techniques for LAA closure. In the literature, there are no studies that assess the impact of LAA in long term follow-up.The dissertation presents the results of a prospective study evaluating the incidence of stroke, thromboembolic events and bleeding after LAA closure in AF patients with high CHADS2-score, CHA2DS2-VAS-score and HAS-BLED in 5,5 years follow-up.Study conducted of 57 patients in study group (LAA Group) and 31 patients in Control Group. 5.5 years follow-up observations showed that LAA closure reduces the risk of stroke and other thromboembolism events. In LAA Group no thromboembolic events were observed. In Control Group thromboembolic events were present in 10% of patients, including CVA in 6.6% of patients. In LAA Groupin patients who stopped OAC there was 6 times less bleeding than in patients who continued OAC.LARIAT device significantly reduces the risk of stroke and thromboembolism events. Moreover, results suggest that stopped oral anticoagulation after epicardial LAA closure does not increase the risk of stroke. LAA closure may be an alternative treatment in AF.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

kardiochirurgia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Krzysztof Bartuś

Date issued:

2016

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4097

Call number:

ZB-124960

ControlNumberVIRTUA:

click here to follow the link

Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

May 24, 2021

In our library since:

Aug 23, 2016

Number of object content hits:

11

Number of object content views in PDF format

11

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4097

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-124960 May 24, 2021
×

Citation

Citation style:

This page uses 'cookies'. More information