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Title: The contribution of mast cells to chronic inflammatory diseases withparticular emphasis on systemic lupus erythematosus

Author:

Kaczmarczyk-Sekuła, Karolina

Date:

2015

Type:

Praca doktorska

Abstract:

The aim of the study was to determine the significance of mast cells inthe pathogenesis of some chronic inflammatory diseases through theanalysis of the number of mast cells and its relationship with theclinicopathological data. The analyzed diseases are systemic lupuserythemtosus, membranoproliferative glomerulonephritis andcutaneous lupus erythematosus.The study was conducted on archivalmaterial collected from the Department of Pathomorphology; thematerial consisted of 148 tissue biopsies, including 103 kidneybiopsies and 45 skin biopsies. Sections were stained by standardhistological and immunofluorescence methods. Theimmunohistochemistry for the presence of chymase and tryptase wasperformed by routine manual method; the cells were counted withmicroscope and expressed as a sum of positive cells from 10 highpower fields. The assessment of relative interstitial volume was donewith microscope and rectangular eyepiece grid. The statistical analysisshowed the difference in the number of chymase- and tryptase-positivemast cells in the renal interstitium between classes of systemic lupuserythematosus, between systemic lupus class IV andmembranoproliferative glomerulonephritis and in the number ofchymase- and tryptase-positive mast cells between systemic lupuserythematosus, discoid lupus erythematosus and subacute lupuserythematosus, within skin biopsies.The results indicate theinvolvement of mast cells in the pathogenesis of chronic inflammatorydiseases, including the pathogenesis of systemic lupus erythematosus.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

patomorfologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Krzysztof Okoń

Date issued:

2015

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4092

Call number:

ZB-124674

ControlNumberVIRTUA:

click here to follow the link

Language:

eng ; pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Subject and keywords:

SLE DLE chymase ryptase mast cells

Object collections:

Last modified:

May 24, 2021

In our library since:

Jun 8, 2016

Number of object content hits:

12

Number of object content views in PDF format

12

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4092

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Edition name Date
ZB-124674 May 24, 2021

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