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Title: Research on the development of methods for the determination and selected aspects of toxicology and pharmacology of new designer drugs

Abstract:

New designer drugs or new psychoactive substances (NPS) create a group of psychoactive compounds selling as preparations in the form of powders, tablets, capsules and plant-derived substances labeled “not for human consumption”. They were advertised as legal and safe alternative to conventional drugs. The paper presents the results of identification for more than 1300 products. The prepared samples were identified by means of GC-EI-MS. The analysis revealed the following substances in the investigated products: piperazine derivatives (including BZP, MPMP, TFMPP), cathinone derivatives (including: 3-MMC, buthylone, pentedrone), pyrovalerone derivatives (MDPV), synthetic cannabinoids (such as AM-2201, UR-144, JWH-073, JWH-081). The separate subject of the study was complex analysis of 9 cases with using GC-EI-MS and LC-ESI-MS/MS methods. Three studied cases concerned people under the influence of NPS: 2 people under the influence of derivative of cathinone (α-PVP) and one, who was under the influence of synthetic cannabinoid – AM-2201. Six of the cases were associated with fatal poisonings: 4 concerned overdose of cathinones (buthylone, mephedrone, 4-MEC, α-PVP) and 2 were related to the accident on the road (α-PVP). The last part of the study was related to behavioral studies on animals. Subject concerned two synthetic cannabinoids - JWH-081 and UR-144, which were selected on the base of analysis of “legal highs” products. The experiments demonstrated that these synthetic cannabinoid substituted for Δ9-THC. The subjective effects of JWH-081 and UR-144 corresponds to their affinity for the CB1 receptors.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmakologia ; medycyna sądowa

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Małgorzata Kłys ; Małgorzata Filip

Date issued:

2015

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4074

Call number:

ZB-124222

ControlNumberVIRTUA:

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Language:

pol

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

May 24, 2021

In our library since:

Apr 15, 2016

Number of object content hits:

4

Number of object content views in PDF format

4

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4074

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ZB-124222 May 24, 2021
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